TABLE 6.
Functional distribution of UPF-dependent mRNAs
| MIPS category | No. (%)
|
|
|---|---|---|
| Transcriptome (6,233 ORFs)a | UPF-dependent (529 mRNAs)b | |
| Metabolism | ||
| Energy | 236 (3.7) | 23 (4.3) |
| Growth, division, DNA synthesis | 753 (12.1) | 44 (8.3) |
| Transcription | 722 (11.6) | 39 (7.3) |
| Protein synthesis | 343 (5.5) | 5 (0.9) |
| Protein destination | 512 (8.2) | 20 (3.8) |
| Transport facilitation | 300 (4.8) | 32 (6.0) |
| Intracellular transport | 414 (6.6) | 20 (3.8) |
| Cellular biogenesis | 170 (2.7) | 12 (2.3) |
| Signal transduction | 119 (1.9) | 4 (0.8) |
| Rescue, defense, death, aging | 311 (5.3) | 40 (7.6) |
| Ionic homeostasis | 114 (1.8) | 5 (0.9) |
| Cellular organization | 2,105 (33.8) | 107 (20.2) |
| Unclassified | 2,605 (41.8) | 260 (49.1) |
| Intron containingc | 248/6,218 (4.0) | 21/529 (3.6) |
Based on functional assignments made by MIPS (as of the 16 July 1998 MIPS update). To calculate the percentages, the denominator of 6,233 was used, which represents the number of unique ORFs in the MIPS database. The percentages do not sum to 100% because a substantial number of mRNAs have been assigned to more than one category.
Based on functional assignments of the UPF-dependent mRNAs that increase in abundance (529 unique mRNAs with CKI scores of ≥0.44). To calculate the percentages, the denominator of 6,218 was used, which represents the number of unique ORFs represented on the HDOA. The percentages do not sum to 100% because a substantial number of mRNAs are listed in more than one category.
Percentage of intron-containing mRNAs among 6,218 ORFs uniquely tiled on the HDOA and percentage of intron-containing mRNA among the 529 unique UPF-dependent mRNAs with CKI scores of ≥0.44.