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. 2021 Aug 29;14(9):873. doi: 10.3390/ph14090873

Table 6.

Oral side effects of Slovak healthcare workers who received BNT162b2 and stratified by gender, February–March 2021 (n = 522).

Variable Outcome Female (n = 402) Male (n = 120) Total (n = 522) Sig.
Oral Side Effect Prevalence Ulcers 8 (2%) 2 (1.7%) 10 (1.9%) 1.000
Vesicles 6 (1.5%) 2 (1.7%) 8 (1.5%) 1.000
Blisters 8 (2%) 3 (2.5%) 11 (2.1%) 1.000
White/Red Plaque 6 (1.5%) 1 (0.8%) 7 (1.3%) 1.000
Angular Cheilitis 6 (1.5%) 0 (0%) 6 (1.1%) 0.345
Halitosis 6 (1.5%) 1 (0.8%) 7 (1.3%) 1.000
Xerostomia 2 (0.5%) 0 (0%) 2 (0.4%) 1.000
Burning/Bleeding Gingiva 16 (4%) 1 (0.8%) 17 (3.3%) 0.139
Taste Disturbance 1 (0.2%) 0 (0%) 1 (0.2%) 1.000
Oral Paraesthesia 4 (1%) 0 (0%) 4 (0.8%) 0.578
Intensity (0–10) 0.16 ± 0.54 0.08 ± 0.36 0.14 ± 0.51 0.118
Total (n) 43 (10.7%) 7 (5.8%) 50 (9.6%) 0.112
Oral Side Effect Onset 1–3 days 9 (21.4%) 1 (14.3%) 10 (20.4%) 0.467
1st Week 8 (19%) 2 (28.6%) 10 (20.4%) 1.000
2nd Week 9 (21.4%) 1 (14.3%) 10 (20.4%) 0.467
3rd Week 11 (26.2%) 2 (28.6%) 13 (26.5%) 0.742
4th Week 5 (11.9%) 1 (14.3%) 6 (12.2%) 1.000
Ulcers, Vesicles, and Blisters
Location
(n = 15)
Tongue 4 (36.4%) 0 (0%) 4 (26.7%) 0.516
Palate 2 (18.1%) 1 (25%) 3 (20%) 1.000
Labial/Buccal Mucosa 6 (54.5%) 1 (25%) 7 (46.7%) 0.569
Gingiva 3 (27.3%) 2 (50%) 5 (33.3%) 0.560
Lips 1 (9.1%) 1 (25%) 2 (13.3%) 0.476
White or Red Plaque Location
(n = 7)
Tongue 4 (66.7%) 0 (0%) 4 (57.1%) 0.429
Soft Palate 1 (16.7%) 1 (100%) 2 (28.6%) 0.286
Labial/Buccal Mucosa 2 (33.3%) 0 (0%) 2 (28.6%) 1.000

Chi-squared test (χ2), Fisher’s exact test, and Mann–Whitney test (U) were used with a significance level (Sig.) of < 0.05.