Table 1.
Relevant Gene Sets enriched in leukemic B cells compared to normal B cells as revealed by RNA sequencing analysis and GSEA. NES, normalized enrichment score. NOM p-val, nominal p-value.
| Rank | GeneSets | SIZE | NES | NOM p-Val |
|---|---|---|---|---|
| 1 | HALLMARK_MYC_TARGETS_V1 | 200 | 1.46 | 0.000 |
| 2 | HALLMARK_CHOLESTEROL_HOMEOSTASIS | 73 | 1.45 | 0.000 |
| 3 | HALLMARK_GLYCOLYSIS | 200 | 1.4 | 0.000 |
| 4 | HALLMARK_E2F_TARGETS | 200 | 1.4 | 0.185 |
| 6 | HALLMARK_MYC_TARGETS_V2 | 57 | 1.38 | 0.000 |
| 7 | HALLMARK_OXIDATIVE_PHOSPHORYLATION | 197 | 1.35 | 0.000 |
| 8 | HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY | 49 | 1.34 | 0.000 |
| 9 | HALLMARK_FATTY_ACID_METABOLISM | 157 | 1.34 | 0.000 |
| 10 | HALLMARK_G2M_CHECKPOINT | 196 | 1.29 | 0.185 |
| 11 | HALLMARK_UV_RESPONSE_UP | 156 | 1.28 | 0.000 |
| 15 | HALLMARK_HYPOXIA | 198 | 1.22 | 0.000 |
| 16 | HALLMARK_P53_PATHWAY | 200 | 1.22 | 0.084 |
| 18 | HALLMARK_IL2_STAT5_SIGNALING | 199 | 1.2 | 0.094 |
| 20 | HALLMARK_MTORC1_SIGNALING | 199 | 1.18 | 0.287 |
| 21 | HALLMARK_UNFOLDED_PROTEIN_RESPONSE | 112 | 1.15 | 0.185 |
| 24 | HALLMARK_MITOTIC_SPINDLE | 199 | 1.13 | 0.269 |
| 25 | HALLMARK_DNA_REPAIR | 148 | 1.13 | 0.084 |
| 28 | HALLMARK_XENOBIOTIC_METABOLISM | 196 | 1.09 | 0.299 |
| 30 | HALLMARK_APOPTOSIS | 161 | 1.01 | 0.376 |
| 31 | HALLMARK_IL6_JAK_STAT3_SIGNALING | 87 | 1.01 | 0.381 |
| 32 | HALLMARK_PROTEIN_SECRETION | 96 | 1.01 | 0.472 |
| 33 | HALLMARK_WNT_BETA_CATENIN_SIGNALING | 41 | 1 | 0.362 |