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. 2021 Aug 26;14(9):847. doi: 10.3390/ph14090847

Figure 1.

Figure 1

Simplified illustration of the differences of α-syn deposition and structure in PD, DLB, and MSA neurodegenerative diseases. In particular, LB-rich brain regions deposited in the cingulate cortex are thought to be specific for PD and DLB, while depositions within the cerebellum are specific for MSA. Additionally, inclusions of α-syn are found in neuronal cells in PD and DLB. Conversely, in MSA these inclusions are found in oligodendrocytes ((left), visualized with BioRender). Structural differences of α-syn have been reported in patient-derived α-syn fibrils (right). (Adapted from [24] and visualized with BioRender).