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. 2021 Aug 26;14(9):847. doi: 10.3390/ph14090847

Figure 6.

Figure 6

Phenothiazine analogues with binding properties determined from two different assays. a Affinity toward α-syn fibrils determined by ThT fluorescence assay [92]. b Affinity toward recombinant α-syn and tau and synthetic Aβ1–42 fibrils determined by [125I]SIL23 competition assay [55]. c Affinity toward human PD brain homogenate determined by [125I]SIL23 competition assay [55]. * Kd value determined with the radioligand [125I]SIL23 on fibrils or human PD brain homogenate. * clogP computed from BioByte software. ** clogD7.4 computed from ACD/Percepta. n.d.: not determined.