Figure 14.

Chemical structures of bithiazole derivatives with key properties. Chemical structure of potential α-syn ligands with binding properties toward recombinant α-syn, Aβ_1–42, and tau fibrils. ^a Affinity toward α-syn fibrils, synthetic amyloid peptides (Aβ_1–42) and human recombinant tau-441 determined by saturation binding assay [107]. ^b % inhibition of [³H]PIB determined by competition binding assay [107]. ^c calculated clogP according to the reference [107]. ^d Measured logP from octanol/PBS study according to the reference [107]. n.d.: not determined. * clogP values were calculated by BioByte. ** clogD_7.4 values calculated by ACD/Percepta. *** Literature source [108].