Figure 23.
Chemical structures of new quinolinyl analogs. (A) General structures 11 and 12 of quinolinyl analogs. (B) Chemical structures of new radiolabeled quinolinyl analogs [11C]52, [18F]53 and [18F]54. a Binding affinities expressed as Ki values determined by ThT indirect competitive binding using recombinant α-syn fibrils. b Binding affinities expressed as Kd values and determined by direct radioligand competitive binding using recombinant α-syn fibrils. c Binding affinities expressed as Kd values and determined by direct radioligand competitive binding assay on tissue homogenates from AD patients [134]. * clogP values were calculated by BioByte. ** clogD7.4 values calculated by ACD/Percepta. (C) Chemical structure of [125I]TZ6184 with binding affinity Kd = 0.39 nM [135].