Figure 24.

Chemical structures of N-phenylbenzamide analogues. (A) General structure of N-phenylbenzamide analogues (general structure 13) that showed to be high affinity displacers and chemical structure of [³H]55. Key properties are summarized in table below [136]. (B) Chemical structure of [³H]59 and its binding to human AD brain tissue (cortical tissue) and comparison with staining of anti-Aβ mAb (adapted from Borroni et al. [136]). * clogP values were calculated by BioByte. ** clogD_7.4 values calculated by ACD/Percepta.