Figure 6.
Target prediction analysis for the 5 miRNA sets was performed with miRTarbase and miRGate online tools. (A) Most relevant targeted pathways, according to Reactome and String analysis for each target-gene list. Mostly, genes related to transcriptional regulation and signal transduction were overrepresented (+++, ≥40% of the pathways related; ++, 20–40% of related pathways; +, up to 20% of the defined pathways). (B) Venn diagram comparing altered pathways in the 5 miRNA sets defined. In PD, 63 pathways were specifically altered, and 31 were associated with DLB in comparison to AD and PD.