Table 5.
Antileishmanial and antimicrobial activity of compounds 1–8.
| Compound | Antileishmanial | Antimicrobial | |||
|---|---|---|---|---|---|
| Inhibition of Parasites (%) a | Cell Viability (%) b | C. albicans | S. aureus | E. coli | |
| IC50 (μg/mL) | |||||
| 1 | −5.3 | 96.2 | NAc | NA | NA |
| 2 | 1.4 | 96.5 | NA | NA | NA |
| 3 | 58.7 | 88.8 | NA | NA | NA |
| 4 | −11.9 | 97.1 | NA | NA | NA |
| 5 | −12.3 | 97.0 | NA | NA | NA |
| 6 | 74.3 | 106.2 | NA | >104 | NA |
| 7 | 54.7 | 96.1 | NA | NA | NA |
| 8 | 39.0 | 92.7 | NA | NA | NA |
| kanamycin | NA | 13.5 | 1.50 ± 0.24 | ||
| nystatin | 0.93 ± 0.18 | NA | NA | ||
a Inhibition of a growth of L. donovani at 50 μM, b Cell viability of compounds in THP-1 cell at 50 μM, NA: Not active at 500 μg/mL.