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B cell function and modes of intervention. (A) The effector functions of B cells in the immune system, including the IL-10 producing regulatory B cells. (B) Modes of B cell depletion. Antibodies directed against the B cell-specific markers CD19 and CD20 will deplete all B cells, while chimeric auto-antibody receptor T (CAAR-T) cells and chimeric antibody receptor (CAR)-Tregs can be specifically targeted to autoreactive B cells.
