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Schematic workflow of the methodology for determining the central nervous system (CNS) drug disposition of actinomycin D (Act D). Despite the use of actinomycin C (Act C) for probe calibration and avoiding nonspecific binding of actinomycin D to the microdialysis equipment, only whole brain tissue measurements were suitable for measurement of the drug´s brain disposition. Created with BioRender (Biorender AG, Münchwilen, Switzerland).
