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. 2021 Sep 3;10(9):2305. doi: 10.3390/cells10092305

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Correlation analysis. (Aa) Significant positive correlation between residual perfusion recovery perfusion recovery evaluated by ¹⁸F-FDG microPET signal expressed as heart-to-muscle ratio on day 30 and ⁶⁸Ga-sCD146 microPET signal intensity expressed as heart-to-muscle ratio on day 15 post-myocardial infarction (Pearson R² = 0.70; p = 0.04; n = 7). (Ab) No significant correlation was observed between individual residual perfusion recovery and ⁶⁸Ga-RGD₂ microPET signal intensity on day 14 post-ischemia (Pearson R² = 0.21; p = 0.64; n = 7). (Ba): Significant negative correlation was detected between individual fibrosis quantification evaluated by histological Sirius red staining and expressed as percentage of fibrosis tissue on left ventricle 43 days post-myocardial infarction and ⁶⁸Ga-sCD146 microPET signal intensity expressed as heart-to-muscle ratio on day 15 post-ischemia (Pearson R² = −0.77; p = 0.04; n = 7). (Bb) No significant correlation was observed between individual fibrosis damages on day 43 post-ischemia and ⁶⁸Ga-RGD₂ PET signal on day 15 post-ischemia (Pearson R² = −0.68; p = 0.06; n = 7). (Ca) a significant positive correlation was found between individual functional recovery explored with ultrasound imaging and expressed as the ratio between VEF 43 and 22 days post-myocardial infarction and ⁶⁸Ga-sCD146 microPET signal intensity expressed as heart-to-muscle ratio on day 15 post-myocardial infarction (Pearson R² = 0.68; p = 0.01; n = 12). (Cb) A significant correlation is identified between individual functional recovery and ⁶⁸Ga-RGD₂ microPET signal intensity on day 15 post-ischemia (Pearson R² = 0.59; p = 0.04; n = 12). (Da) A significant negative correlation was identified between individual fibrosis on day 43 post-ischemia and ¹⁸F-FDG PET signal intensity ratio on day 16 post-ischemia (Pearson R² = −0.83; p = 0.024; n = 10). (Db) No significant correlation was detected between functional recovery, ratio D43 on D22 post-myocardial infarction and ¹⁸F-FDG PET signal intensity ratio on day 16 post-ischemia (Pearson R² = −0.39; p = 0.25; n = 10).