Table 1.
Morphometric analysis of the incretory apparatus of rats during DM and on the background of Galega officinalis extract administration.
| Parameters | Groops | |||||
|---|---|---|---|---|---|---|
| C | C + G600 * | C + G1200 * | D | D + G600 * | D + G1200 * | |
| The number of islets of Langerhans on a standard area (N/10 mm2) | 15.91 ± 0.955 | 14.94 ± 0.945 | 15.65 ± 0.595 | 4.420 ± 0.743 a | 5.673 ± 0.631 a | 6.640 ± 0.605 ab |
| Islets area (μm2) | 10,440 ± 358.5 | 9785 ± 523.7 | 10,900 ± 388.2 | 4620 ± 497.0 a | 5354 ± 387.4 a | 6623 ± 331.2 abc |
| Islets diameter (μm) | 160.7 ± 3.814 | 152.6 ± 5.658 | 161.9 ± 5.548 | 106.5 ± 4.669 a | 113.7 ± 3.752 a | 119.7 ± 4.663 a |
| Islets volume (μm3) | 2.20 × 106 ± 1.52 × 105 |
1.92 × 106 ± 2.29 × 105 | 2.28 × 106 ± 2.38 × 105 | 6.58 × 105 ± 8.88 × 104 a | 7.88 × 105 ± 7.40 × 104 a | 9.28 × 105 ± 11.37 × 104 a |
| Number of β-cells/1000 μm² | 7.79 ± 0.280 | 7.18 ± 0.192 | 8.09 ± 0.308 | 4.74 ± 0.174 a | 5.12 ± 0.325 a | 5.62 ± 0.145 ab |
a—p < 0.05, as compared with the control group; b—p < 0.05, as compared with the diabetes mellitus group; c—p < 0.05, as compared with the group of animals D + G600. * C + G600, C + G1200—control animals that were treated with extract of Galega officinalis at doses 600 mg and 1200 mg/kg per day, respectively; D + G600, D + G1200—animals with diabetes that were treated with extract of Galega officinalis at doses 600 mg and 1200 mg/kg per day, respectively.