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. 2021 Sep 15;13(9):1472. doi: 10.3390/pharmaceutics13091472

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Confocal microscopy analysis of intracellular disposition of mRNA- and pDNA-based vectors 4 h after their addition in HCE-2 cells. (A) CleanCap™ Cyanine 5 EGFP mRNA (5moU) vectors formulated with P, DX and HA. (B) pcDNA3-EGFP plasmid labeled with Label IT^® Cy^®5 vectors. Blue: nuclei labeled with DAPI. Red: fluorescence signal of nucleic acid labeled with Cy^®5. Magnification 60×. Scale bar: 15 µm. DX: dextran; HA: hyaluronic acid; SLN_EE: solid lipid nanoparticle prepared by emulsification-evaporation method. SLN_HM: solid lipid nanoparticle prepared by hot-melt emulsification method. SLN_C: solid lipid nanoparticle prepared by coacervation method.