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. 2021 Sep 18;10(9):934. doi: 10.3390/biology10090934

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Lymphedema results in increased epidermal expression of Th2-inducing cytokines. This phenotype is mitigated by treatment with QBX258. (a) Representative immunofluorescent staining (left panels) and quantification (right panel) of TSLP (green) in normal, LE, and LE + tx biopsy specimens. (b) Representative immunofluorescent staining (left panels) and quantification (right panel) of IL33 (red) in normal, LE, and LE + tx biopsy specimens. (c) Representative immunofluorescent staining (left panels) and quantification (right panel) of IL25 (green) in normal, LE, and LE + tx biopsy specimens. (d) Representative immunofluorescent staining (left panels) and quantification (right panel) of IL13R (green) in normal, LE, and LE + tx biopsy specimens. Scale bar: 100 μm; * p < 0.05; ** p < 0.01.