Table 1.

Inclusion and exclusion criteria.

Inclusion	Exclusion
Women 18–70 with unilateral stage I or II BCRL	Bilateral lymphedema or history of bilateral axillary lymph node dissection
Volume difference of at least 300 mL between the normal and lymphedema limb	Recent (within last 3 months) history of cellulitis
BMI 18–30	Current (within last month) use of chemotherapy or radiation
No current evidence of breast cancer	Recent (within last month) or current intensive manual lymphatic massage and/or short stretch bandage use
At least 6 months postop from axillary lymph node dissection	Unstable lymphedema (i.e., worsening symptoms/measurements in the past 3 months)
	Pregnant or nursing (lactating) women
	Stage III lymphedema
	Chronic use of acetaminophen (>1 gm/day for ≥3/7 days, or >2 gm/day for ≥1 day)
	Use of other investigational drugs ≤30 days or 5 half-lives of enrollment (whichever is longer)
	History of hypersensitivity to study drugs or to drugs of similar chemical classes (e.g., monoclonal antibodies, polyclonal gamma globulin, polysorbates).