Table 1.

Summary of the effects of silver nanoparticles on different types of cell lines: normal human lung fibroblast cells (IMR-90); pulmonary epithelial (A549), renal epithelial (A498), neuronal (Neuro 2A) cell lines; human Chang liver cells; human glioblastoma cells (U251); human hepatocellular carcinoma cells (HepG2); human fibrosarcoma (HT-1080), human skin carcinoma (A431); human lung carcinoma epithelial-like cell line (A549); Chinese hamster ovary cells (CHO); macrophage (RAW 264.7, J774.1) cell lines; mouse peritoneal macrophage cell line (RAW264.7); primary bovine retinal endothelial cells (BREC); immortalized human pancreas duct epithelial cell line hTERT-HPNE (CRL-4023); human pancreatic ductal carcinoma PANC-1 (CRL-1469); human colonic epithelial cell line (HT29); human stomach cancer cells (SGC-7901), and human breast adenocarcinoma cells lines (MCF-7).

Tested Nanoparticle Parameter	Type of Cells			Effect
	Normal Human Cells	Human Tumor Cells	Animal Cells
Increase in AgNP concentration	IMR-90 [76];	U251 [76];	CHO [83];	Decrease of cell viability and increased apoptosis, increased ROS production
	A549, A498, Neuro 2A [77];	Hep G2 [77,80];	RAW 264.7, J774.1 [77];
	human Chang liver cells [78];	HT-1080, A431 [81];	RAW264.7 [84];
	CRL-4023 [79];	A549 [82];	BREC [85];
		CRL-1469 [79];
Smaller AgNP size	IMR-90 [75];	human glioblastoma cells [76];	BREC [85]	Increased toxicity
	lymphocyte cell [86];	A549, SGC-7901, HepG2, MCF-7 [87];	Primary rat brain microvessel endothelial cells [88]
	rat alveolar macrophages [89];
	HT29 [73];