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The combination of 3-OBA and metformin inhibits HT29 tumor cell growth in vivo. BALB/c nude mice (n = 6) were intraperitoneal injected with 75 mg/kg of 3-OBA, 200 mg/kg of metformin, and the combination, (A) tumor volumes and (B) body weights were measured every other day. (C) Lactate concentration in serum after different treatments. * p < 0.05, ** p < 0.01.
