Table 5.

Medications that increase the risk of hyperkalemia.

Medication	Mechanism
nonsteroidal anti-inflammatory drugs	reduce renal blood flow, decrease renin secretion
trimethoprim	inhibits aldosterone-sensitive sodium channels in the distal nephron
cyclosporine	reduces potassium secretion in the collecting duct, interferes with renin release
azole antifungals	reduce aldosterone levels
heparin	inhibits aldosterone production
beta-blockers	reduce renin secretion and alter transmembrane potassium movement
angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers	reduce potassium secretion