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1H11 induces OC cell cytotoxicity and cell cycle arrest. (A–C) Evaluated by SRB assay, 1H11 selectively inhibited OC cell proliferation with an EC50 of 260 nM in both (A) OVACR8 and (B) SKOV3 with no cytotoxic effects on (C) FT132. (D) Cell-cycle analysis of OVCAR8 cells treated for 72 h was performed by flow cytometry. Significant G0/G1 cell-cycle arrest was induced in a dose-dependent manner by 1H11. All data plotted as mean ± SEM. *** p < 0.001, ** p < 0.01 vs. IgG.
