Figure 4.

1H11 inhibits OC cell migration. A scratch assay was used to evaluate the migration ability of cells treated with 2 µM 1H11 or IgG. Wounds inflicted on (A) SKOV3 and (D) OVCAR8 were imaged for up to 48 h. Representative images are shown with a scale bar = 200 µm. (B,E) Quantification of wound closure demonstrates that 1H11 inhibited cell motility. Similarly, treatment with 1H11 significantly reduced the migration rate of (C) SKOV3 and (F) OVCAR8. All data plotted as mean ± SEM. *** p < 0.001, ** p < 0.01, * p < 0.05 vs. IgG.