Figure 6.

1H11 does not induce major toxic effects. Athymic nude mice with subcutaneously implanted OVCAR8 tumors were treated for one week with 5 mg/kg 1H11 or IgG. (A) Chemistry tests for alanine transaminase (ALT), blood urea nitrogen (BUN), and creatinine were conducted from serum samples. No significant changes were observed between groups. All data plotted as mean ± SEM, non-significant (ns) vs. IgG. (B) Kidney, spleen, and liver samples stained with H&E showed no major histological difference. Representative images are shown with a scale bar = 100 µm.