Figure 2.

CBD does not prevent STZ-induced beta cell loss. (a) Representative images of immunofluorescent staining of insulin (green) and nuclei (DAPI, blue) of the pancreas from control, vehicle-STZ and CBD-STZ-treated mice (original magnification ×25, scale bar 50 μm). Quantification of (b) intra-islet staining and (c) beta cell mass (calculated as total beta cell area) per islet. N = 100 islets/group. Values are expressed as mean ± SEM (n = 6–7 animals per group). *** p < 0.001 vs. vehicle-citrate buffer-treated mice (control).