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. 2021 Sep 25;19:97. doi: 10.1186/s12964-021-00743-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Ym155 regulates BMP signaling in lung cancer cells. A Immunoblot of tumors treated with JL5 for 4 days. B, C Western blot analysis of cells treated with Ym155 for 24 h. D, E Western blot analysis of BMP signaling following treatment with Ym155 for 24 h. F H1299 cells stably transfected with Id1-luciferase reporter were treated with Ym155 for 24 h and relative luminescence units (RVU) measured. Data shown is the mean of 2 independent experiments. G H1299 cells were transiently transfected with control vector or caBMPR1 then treated with Ym155. Western blot analysis of transfected cells treated with Ym155 for 24 h. H Data shows the mean of percent live cells of 3 independent experiments after being treated with Ym155 for 48 h. J Dose response curves of the number of live cells after being treated with Ym155 (I) or JL5 for 24 h