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. 2021 Sep 25;19:97. doi: 10.1186/s12964-021-00743-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Inhibition of BMPR2 activates lysosomes in sensitive lung cancer cell lines but not in MDA-MB-468 cells. A Immunofluorescence imaging of LAMP1 in treated A549 cells treated with JL5. (B-C) Immunofluorescence imaging for Lysotracker™ Green and Green Cathepsin B of A549 treated with JL5 for 24 h. D Immunofluorescence imaging of Lysotracker™ Green of H1299 treated with JL5. E Immunofluorescence imaging for LAMP1 and Lysotracker™ Green of cells treated with DMH1 for 24 h. F–G Immunofluorescence imaging for Lysotracker™ Green and Green Cathepsin B of A549 cells transfected with control or BMPR2 siRNA for 48 h. H, I Immunofluorescence imaging for Lysotracker™ Green and LAMP1 of MDA-MB-468 cells treated for 24 h with JL5. (J-K) Immunofluorescence imaging Lysotracker™ Green of H1299 and MDA-MD-468 cells treated with Ym155 for 24 h. Each scale bar represents 10 μM