Table 3.

List of genes overlapping candidate age-related genes found in humans and with differential expression between PP (highly expressed) and MP > 3 (highly expressed) cows

	Gene name	Module	Description	Reference
PP	CCR7	darkred	Control the migration of memory T cells to inflamed tissues, as well as stimulating dendritic cell maturation	[28]
	CD27	midnightblue	Required for generation and long-term maintenance of T cell immunity	[28]
	FOXO1	midnightblue	Transcription factor which may play a role in myogenic growth and differentiation	[29]
	IL7R	midnightblue	Plays a critical role during lymphocyte development (age and longevity expression association)	[30]
	CAMK4	midnightblue	Implicated in transcriptional regulation in lymphocytes, neurons and male germ cells (longevity genetics candidate)	[31]
	CD28	midnightblue	Essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development	[28]
	WRN	yellow	RecQ helicase important in the maintenance of genome stability. Mutations cause Werner syndrome (premature ageing)	[32]
	MRPS27	yellow	Mitochondrial ribosomal protein assisting protein synthesis within the mitochondrion (mitochondrial ageing)	[33]
	MRPS9	yellow	Mitochondrial ribosomal protein assisting protein synthesis within the mitochondrion (mitochondrial ageing)	[33]
	MRPS31	orange	Mitochondrial ribosomal protein assisting protein synthesis within the mitochondrion (mitochondrial ageing)	[33]
MP > 3	SREBF1	black	Transcription factor involved in sterol biosynthesis	[29]
	ANXA5	turquoise	Potential role in cellular signal transduction, inflammation, growth and differentiation	[34]
	LYZ	turquoise	Antimicrobial peptide	[34]
	CTSZ	turquoise	Lysosomal cysteine protease with role in immune defense	[34]
	ADARB1	turquoise	Enzyme in the A (adenosine) to I (inosine) RNA editing pathway, involved in a general maintenance of cellular health (longevity genetics candidate)	[35]
	GRN	turquoise	Granulin precursor protein which regulates cell growth. Also, co-ordinates CpG trafficking to TLR9, promoting activation of signalling cascade	[34]