Table 3.
Outcomes of microbiota changes in the included studies
| First Author | year | Detection method | Results of microbiota diversity analysis | Increased intestinal flora after RT | Decreased intestinal flora after RT | Increased intestinal flora before RT in diarrhea | Decreased intestinal flora before RT in diarrhea | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Phylum | Genus | Phylum | Order/genus | Phylum | Genus/class | Phylum | Genus/class | ||||
| Mitra | 2020 | 16 s-rRNA | After RT, the diversity of microbiota decreased in patients with diarrhoea | – | Phascolarctobacterium Lachnospiraceae Veillonella Erysipelotrichaceae | – | Order: Clostridiales | – | Class: Sutterella, Finegoldia, Peptococcaceae (Clostridia) | – | Clostridiales |
| Wang | 2019 | 16 s-rRNA | Patients with diarrhoea present reduced α‐diversity but increased β‐diversity of microbiota | – | – | – | – | Proteobacteria | Class: Gammaproteobacteria Genus: Serratia, Prevotella_9 Coprococcus Desulfovibrio | Bacteroidetes Firmicutes | Genus: Bacteroides, Blautia, Ruminococcaceae_UCG‐003 |
| Reis Ferreira | 2019 | 16 s-rRNA | After RT, the diversity of microbiota decreased in patients with diarrhoea | – | Roseburia Clostridium IV Phascolarctobacterium | – | – | – | Genus: sutterella | – | Genus: Roseburia |
| Medrano | 2017 | 16 s-rRNA | After RT, the diversity of microbiota decreased and intestinal function decreased | – | – | – | – | – | – | – | – |
| Wang | 2015 | 16 s-rRNA | The diversity of microbiota was lower in the diarrhoea group than in the no-diarrhoea and control groups | Unclassified bacteria | Bacteroides Clostridium_XIVa | Firmicutes Bacteroidetes | Genus: Faecalibacterium Lachnospiracea Oscillibacter Roseburia Streptococcus | – | Genus: Bacteroides, Veillonella, Dialister, | – | Genus: Clostridium XI and XVIII, Faecalibacterium, Oscillibacteres, Prevotella, Parabacteroid, unclassified |
| Nam | 2013 | 16 s-rRNA | The diversity of microbiota was decreased during RT and after RT | Fusobacteria Unclassified | Ruminococcus C.methylpentosum leptom | Firmicutes | Genus: Clostridium sp.BG-C36 | – | – | – | – |
| Manichanh | 2008 | 16 s-rRNA | During and after RT, the diversity in the diarrhoea group was lower than that in patients without diarrhoea and controls | – | – | – | – | Actinobacteria Firmicutes | Class: Bacilli | Firmicutes | Class: Clostridia |
| Cuzzolin | 1992 | Bacterial culture | – | Clostridium spp | Clostridium.bistolyticum Clostridium.bifermentans Clostridium.sporogenes | – | Genus: Escherichia coli, Aeromonas hydrophila, Enterococcus faecium 1, Peptococcus Peptostreptococcus spp, Lactobacilli, Fusobacterium Nucleatum total anaerobes | – | – | – | – |
16S rRNA 16S ribosomal RNA sequencing, RT radiation therapy
– Not mentioned in the text