Figure 1.

The effect of HY7715 treatment on age-induced muscle loss in mice. (A) Representative photographs of the mouse groups after 5 weeks of treatment. (B) Weekly body weight measurement, (C) food intake, and (D) water consumption per day. (E) Plasma triglyceride concentrations were detected using a commercial colorimetric enzyme-linked immunosorbent assay (ELISA) kit. (F) Tissue weights of liver, spleen, soleus muscle, and gastrocnemius muscle were measured. Statistical significance was determined using one-way ANOVA followed by Tukey’s post hoc test (N = 6). Datasets denoted by different letters are significantly different; p < 0.05 (a > b > c). YM, young mice; OM, old mice; OM + C, creatine-treated old mice; OM + HY, HY7715-treated old mice.