Figure 2.

The effect of HY7715 treatment on skeletal muscle strength in aged mice. (A) Representative photographs of hind limb muscle (top), gastrocnemius muscle (middle), and soleus muscle (bottom) in the mouse groups after 5 weeks of treatment. (B) The running endurance of the mice was evaluated by a treadmill test. The grip strength of the forelimb (C) and all limbs (D) was measured at 1, 3, and 5 weeks and calculated per body weight. Statistical significance was determined using one-way ANOVA followed by Tukey’s post hoc test (N = 6). Datasets denoted by different letters are significantly different; p < 0.05 (a > b > c). YM, young mice; OM, old mice; OM + C, creatine-treated old mice; OM + HY, HY7715-treated old mice. GA, gastrocnemius; SOL, soleus.