Figure 4.

Inhibition of Inflammasome-associated Gene Expression by RTD-1 Treatment. RTD-1 (7.14 μg/mL) inhibited inflammasome-associated genes in LPS (100 ng/mL)-stimulated THP-1 macrophages. RTD-1 reduced expression of downstream inflammasome molecules. The mRNA transcription profiles obtained using qRT-PCR profiler array were plotted according to the log2-fold change and a log-adjusted p-value. Treatment differences were analyzed using the multiple t-test function in Prism 8.0 software. Statistically significant gene expression changes are represented by data above the dotted horizontal line (p < 0.05). FC, fold change; LPS, lipopolysaccharide; qRT-PCR, quantitative reverse transcription PCR.