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. 2021 Aug 26;10(9):1043. doi: 10.3390/antibiotics10091043

Figure 5.

Figure 5

Inhibition of IL-1β Protein Expression. THP-1 monocytes stimulated with 100 ng/mL LPS were simultaneously treated with RTD-1 (7.14 μg/mL) for 24 h and lysed immediately afterwards to determine the effect on expression of (A) IL-1β and (B) caspase-1 precursor formation. Representative Western blot image is shown in (C). Treatment differences were analyzed using t-tests for IL-1β and caspase-1 (* p ≤ 0.05, ** p ≤ 0.01, *** p < 0.0001). AZM, azithromycin; LPS, lipopolysaccharide; NT, No treatment.