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Esterase-mediated hydrolysis bisubstrate inhibitor prodrugs. (A) Hydrolysis of isopropyl ester prodrug 12e and (B) hydrolysis of isopropyl-TML dual prodrug 14e. The data show clean conversion of the prodrugs to the parent compound 17u. For the dual prodrug 14e, conversion of the TML happens first followed by the hydrolysis of the isopropyl ester moiety.
