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Synthesis of prodrugs 12b–f and 14a–f. Reagents and conditions: (a) aldehydes 5b–f or 9a, NaBH(OAc)3, AcOH, DCE, rt, overnight (34–73%); (b) TFA, CH2Cl2, H2O, rt, 2 h (70–93%); (c) TFA, CH2Cl2, rt, 2 h; (d) TML acid 7, BOP, Et3N, CH2Cl2, rt, 2 h (77–83%).
