Skip to main content
. 2021 Sep 14;11(9):1357. doi: 10.3390/biom11091357

Table 1.

Stability data of the prodrugs in Tris buffer at pH 8.4 and in PBS buffer at pH 7.4. The values indicate the percentage of compound peak area present after 16 h of incubation at room temperature.

graphic file with name biomolecules-11-01357-i001.jpg

Compound Ester R2
(R1 = H)		 Tris PBS Compound Ester R2
(R1 = TML)		 Tris PBS
GYZ-319 H n.a. n.a. 14a H 93.97 99.10
12b Methyl 22.59 36.97 14b Methyl 73.88 88.08
12c Ethyl 54.84 68.36 14c Ethyl 87.00 90.44
12d Propyl 61.32 71.96 14d Propyl 87.52 90.30
12e Isopropyl 93.70 98.59 14e Isopropyl 87.69 91.13
12f Benzyl 21.60 33.43 14f Benzyl n.d. n.d.

n.a. not applicable; n.d. not determined.