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. 2021 Aug 30;10(9):2250. doi: 10.3390/cells10092250

Figure 1.

Figure 1

Milestones in the development of ICB-therapeutics. Discovery of immune checkpoint markers. Year of FDA-approved ICB-antibodies. Factor affecting antibody/drug-resistance. Recent strategies to improve ICB-efficacy by combining molecular medicines. Biopharmaceutical companies developing personalized medicines co-targeting epitranscriptomics and intracellular immune checkpoint (CISH/SOCS-1) in NK-cells, TILs and DCs with relevant clinical trial were summarized.