Table 6.
Amino acid mutations of SARS-CoV-2 Alpha, Beta, Gamma and Delta variants of SARS-CoV-2 with a focus on Spike protein. The domain to which each mutation belongs is indicated in parentheses.
| B.1.1.7 (United Kingdom, Alpha) |
B.1.351 (South Africa, Beta) |
P.1 (Brazil, Gamma) |
B.1.617.2 (India, Delta) |
|---|---|---|---|
| H69–V70 deletion (NTD) | L18F (NTD) | L18F (NTD) | T19R (NTD) |
| Y144 deletion (NTD) | D80A (NTD) | T20N (NTD) | 157-158 Deletion (NTD) |
| N501Y (RBD) | D215G (NTD) | P26S (NTD) | L452 (RBD) |
| A570D | 242-244 deletion (NTD) | D138Y (NTD) | T478(RBD) |
| P681H | R246I (NTD) | R190S (NTD) | D614G |
| T716I | K417N (RBD) | K417T (RBD) | P681R |
| S982A | E484K (RBD) | E484K (RBD) | D950N |
| D1118H | N501Y (RBD) | N501Y (RBD) | |
| D614G | D614G | ||
| A701V | H655Y | ||
| T1027I | |||
| V1176F |