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. 2021 Sep 19;22(18):10127. doi: 10.3390/ijms221810127

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The mRNA levels of Ren and Cd38 with or without the addition of the 8-Br-cADPR. There is no difference in Ren mRNA between 8-Br-cADPR (-) group and 8-Br-cADPR (+) group (1.062-fold increase in 8-Br-cADPR (+), P = 0.604). In contrast, the Cd38 mRNA in 8-Br-cADPR (+) was increased 1.816-fold vs. 8-Br-cADPR (-) (P = 0.0024). Although the mRNA levels of Ren and Cd38 were elevated in response to IH without the 8-Br-cADPR (8-Br-cADPR (-) controls), the elevation of the mRNAs disappeared following the addition of the 8-Br-cADPR (8-Br-cADPR (+)). The data are expressed as the mean ± SE for each group of six independent experiments (n = 6). The statistical analyses were performed using a Student’s t-test.