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Comparison of GSH and tCr in BG (intent to treat analysis). (A) The increase in [GSH] is plotted against the change in [tCR] trough to peak, across all infants with NAC/NVD infusion, including those with only partial infusions. (B,C) The increase in (B) [GSH] and (C) [tCr] are strongly dependent upon the trough concentrations in the BG. There was a significantly greater increase in [GSH] and [tCR] in those with lower CNS GSH and tCr on DOL 5 before dosing (trough).
