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. 2021 Sep 3;11(9):2590. doi: 10.3390/ani11092590

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of different concentrations (50, 100, and 150 mg/kg) of orally administered curcumin on anxiety-like behavior of mice. (a) Percentage of freezing time in dim light at night (dLAN), (b) grooming in dLAN, (c) posture in dLAN, (d) percentage of freezing time in complete darkness (DD), (e) grooming in DD, and (f) posture in DD-exposed mice. Values are represented as mean ± standard deviation (n = 5). Non-parametric one-way ANOVA with post-hoc Dunnett’s test was employed to match the results among different treatment groups. All the data were analyzed with GraphPad Prism-8 software. The statistical values * p < 0.05, ** p < 0.01, and *** p < 0.001 represent a significant difference among the groups.