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. 2021 Sep 3;11(9):2590. doi: 10.3390/ani11092590

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of different concentrations (50, 100, and 150 mg/kg) of orally administered curcumin on the expression fold change of clock gene PER1 in dim light at night (dLAN) and complete darkness (DD)-exposed mice. (a) Light/Dark (LD) control vs. dLAN and DD, (b) dLAN control vs. dLAN treatment, and (c) DD control vs. DD treatment. Values are represented as mean ± standard deviation (n = 5). One-way ANOVA with post-hoc Dunnett’s test was employed to match the results among the different treatment groups in different lighting conditions. All the data were analyzed with GraphPad Prism software. The statistical value *** p < 0.001 represent a significant difference among the groups.