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. 2021 Sep 10;13(18):4557. doi: 10.3390/cancers13184557

Figure 7.

Figure 7

Synergistic effects of autophagy inhibitors and venetoclax. Synergistic effects of dorsomorphin and venetoclax in (a) MEC-1 cells and (b) primary CLL cells derived from 10 patients; Synergistic effects of MRT68921 and venetoclax in (c) MEC-1 cells and (d) primary CLL cells derived from 10 patients; Synergistic effects of chloroquine and venetoclax in (e) MEC-1 cells and (f) primary CLL cells derived from 10 patients. Each square represents the mean relative metabolic activity of cells. For MEC-1 cells experiments were repeated ≥3, each carried out in duplicate. For CLL cells, each column represents responses of individual patient’s cells to different treatments, while each row represents the responses of CLL cells from 10 patients to a specific treatment. One-way ANOVA with Dunnett’s multiple comparisons test was used. *, *** and **** denote p < 0.05, p < 0.001, and p < 0.0001, respectively.