Figure 2.

Pro-tumorigenic functions of exHSP70. MDSC: myeloid-derived suppressor cell; RAGE: receptor for advanced glycosylation endproducts; GSK-3β: glycogen synthase kinase-3β; NO: nitride oxide; TLR: Toll-like receptor; NFκB: nuclear factor kappa-light-chain-enhancer of activated B cells; HSF1: heat shock factor 1; VEGF: vasculogenic endothelial growth factor; pSTAT3: phosphorylated signal transducer and activator of transcription 3; ROS: reactive oxygen species; MyD88: myeloid differentiation primary response 88; PI3K: phosphoinositide 3-kinase; Akt: protein kinase B; MMP: matrix metalloproteinases; HSP70: heat shock protein 70.