Table 4.

Cognitive decline according to the circadian rest-activity pattern

	Model 1		Model 2
	Effect size (95% CI)	p value	Effect size (95% CI)	p value
Intradaily variability
Global	− 0.665 (− 1.190 to − 0.140)	0.014	− 0.715 (− 1.272 to − 0.157)	0.013
Aβ42+	− 0.522 (− 1.147 to 0.103)	0.100	− 0.717 (− 1.391 to − 0.042)	0.038
Interdaily stability
Global	− 0.266 (− 0.818 to 0.286)	0.341	− 0.205 (− 0.817 to 0.407)	0.507
Aβ42+	− 0.108 (− 0.778 to 0.562)	0.747	0.009 (− 0.690 to 0.708)	0.979
Relative amplitude
Global	− 0.495 (− 1.025 to 0.036)	0.067	− 0.587 (− 1.192 to 0.019)	0.057
Aβ42+	− 0.658 (− 1.278 to − 0.038)	0.038	− 0.520 (− 1.202 to 0.163)	0.132

Linear regression models were performed to assess the cognitive decline according to the circadian rest-activity pattern. Model 1, unadjusted analysis; model 2, adjusted for age, sex, T-tau/Aβ42 ratio, educational level, and season of the year

Aβ42 amyloid-beta protein, CI confidence interval, T-tau total-tau