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. 2021 Sep 14;13(18):4607. doi: 10.3390/cancers13184607

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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USP44 methylation and its correlation to PTEN deletions in prostate adenocarcinoma patients. (A) Fraction of genome altered between meth^High and meth^Low groups. Data were obtained by TCGA-PRAD (Firehose Legacy). p > 0.0001. (B) USP44 promoter methylation and correlation to gene deletions in chromosomal region Chr 10 (q23.2-q23.31). Copy number variation data (CNVs) were obtained by TCGA-PRAD (Firehose Legacy). p values underneath the gene names were calculated with Mann-Whitney test. (C) Oncoprints indicating patients with gene deletion events within the chromosomal region Chr 10 (q23.2-q23.31) in meth^High (left) and meth^Low (right) group. Gene deletion frequencies (%) within the group are indicated on the right side of the oncoprint. Oncoprints were generated through cbioportal using CNV data from TCGA-PRAD (Firehose Legacy).