Table 1.
Areas under the concentration–time curves and associated parameters following intravenous and intranasal administration.
| i.v. | i.n. | |
|---|---|---|
|
AUCplsm (ng·min/mL) |
554.9 | 536.8 |
|
AUCCLN (ng·min/g CLN) |
129.9 | 491.0 |
| F (%) | 96.7 | |
| MRTplsm (min) | 24.7 | 31.1 |
| MRTCLN (min) | 56.6 | 146.1 |
| DTI | 3.78 | |
| DTP (%) | 74.3 |
Abbreviations: AUC, area under the plasma concentration–time curve; AUCCLN, area under the cervical lymph node concentration–time curve; F, bioavailability; MRT, mean residence time; DTI, drug targeting index; DTP, direct transport percentage.