Table 2.

Rate constants calculated using WinNonlin.

Rate Constants	min−1
k e	0.0740 ± 0.0208
k a	0.1014 ± 0.0211
k N	0.0047 ± 0.0013
k L	0.0095 ± 0.0039
k p	0.0021 ± 0.0009

The rate constants were determined based on mass balance equations (Figure 2) by adopting noncompartmental and compartmental techniques using the WinNonlin version 6.3 software. Abbreviations: k_e, elimination rate constant; k_a, absorption rate constant; k_N, nasal–cervical lymph node transport rate constant; k_L, cervical lymph node–systemic circulation transport rate constant; k_p, systemic circulation–cervical lymph node transport rate constant.