Figure 7.
Effects of SiNPs on the concentration dependency of the response to ATP. (a–c) Examples of intracellular [Ca2+] traces showing the effects of 100 μg/mL SiNPs on the responses to extracellular ATP applied at 1 μM (a), 10 μM (b) or 100 μM (c). (d) Concentration dependence of the amplitude of the responses to ATP, for the 1st (control), 2nd (in the presence of SiNPs) and 3rd (after washout of SiNPs) applications. The data are represented as mean ± s.e.m. (n = 213, 68, 130, 109, 169 and 146 for ATP 0.3, 1, 3, 10, 30 and 100 μM, respectively).