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. 2021 Sep 11;12(9):1402. doi: 10.3390/genes12091402

Figure 1.

Figure 1

Frequency of KRAS oncogenic mutations across cancer cells lines of different origin. To explore frequency and distribution of KRASm/WT+ and KRASm/WT− mutations across tumor types, KRAS zygosity was retrieved from the COSMIC and the NCI-funded KRAS initiative databases. Mutant KRAS cell lines were classified based on the presence (KRASm/WT+ pink) or absence (KRASm/WT− blue) of the KRAS WT allele. Frequencies of KRASm/WT+ and KRASm/WT− cell lines are displayed as bar graphs; mutations are listed on the x-axis, and number of cell lines identified for each variant is reported on the y-axis. Of the 116 identified cell lines, 38 were derived from lung lesions (32.7%), 33 from pancreatic cancers (28.4%), and 25 from tumors of the large intestine (21.5%). The 36 lung cancer models included in the analysis were established from the following tumors: 22 adenocarcinomas, 4 large cell carcinomas, 2 small cell lung cancers, 2 carcinomas not otherwise specified, 2 giant cell carcinoma, 1 adeno-squamous, 1 squamous carcinoma, 1 carcinoid and 1 epidermoid tumor.