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. 2021 Sep 11;12(9):1402. doi: 10.3390/genes12091402

Figure 6.

Figure 6

Drug sensitivity assay and changes in FoxM1 expression after treatment with Palbociclib and Siomycin in KRASm/WT+ and KRASm/WT− NSCLC cell lines. Line plots show cell viability after 72 hours of incubation with Palbociclib and Siomycin in KRASm/WT− (A549, H1373 and H2122; blue lines) and KRASm/WT+ (A427, H23 and H358; red lines) cell lines (A,B). Data were normalized on matched vehicle control samples, namely PBS and DMSO for Palbociclib and Siomycin, respectively. Changes in FoxM1 phosphorylation levels after 72 hours of incubation with 0.6 µM of Siomycin were captured in KRASm/WT+ and KRASm/WT− lines using the RPPA (C). * Indicates stop codon.